Protein–Protein Interaction Hotspots Carved into Sequences
نویسندگان
چکیده
منابع مشابه
Protein–Protein Interaction Hotspots Carved into Sequences
Protein-protein interactions, a key to almost any biological process, are mediated by molecular mechanisms that are not entirely clear. The study of these mechanisms often focuses on all residues at protein-protein interfaces. However, only a small subset of all interface residues is actually essential for recognition or binding. Commonly referred to as "hotspots," these essential residues are ...
متن کاملConfigurable Hotspots for Ubiquitous Interaction
In this paper we describe our configurable hotspot framework for ubiquitous interaction. A camera points to a physical space, the user defines interaction areas, and designs gestures by combining hotspots (rectangles) that detect simple 2D motions (left_right, top_bottom, etc.).
متن کاملCombiMotif: A new algorithm for network motifs discovery in proteinprotein interaction networks
Discovering motifs in protein–protein interaction networks is becoming a current major challenge in computational biology, since the distribution of the number of network motifs can reveal significant systemic differences among species. However, this task can be computationally expensive because of the involvement of graph isomorphic detection. In this paper, we present a new algorithm (CombiMo...
متن کاملIncorporating evolutionary history into conservation planning in biodiversity hotspots.
There is increased evidence that incorporating evolutionary history directly in conservation actions is beneficial, particularly given the likelihood that extinction is not random and that phylogenetic diversity (PD) is lost at higher rates than species diversity. This evidence is even more compelling in biodiversity hotspots, such as Madagascar, where less than 10% of the original vegetation r...
متن کاملIncorporating socioeconomic factors into the analysis of biodiversity hotspots
Hotspot analysis is the identification and ranking of countries or other geographic regions on the basis of biodiversity. Hotspots have exceptional biodiversity per unit land area. This paper introduces a new method of hotspot analysis that ranks hotspots on the basis of biodiversity and anthropogenic threats to biodiversity. These threats are represented by socioeconomic factors such as human ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS Computational Biology
سال: 2007
ISSN: 1553-7358
DOI: 10.1371/journal.pcbi.0030119